Toshi Reagon (born in Atlanta in 1964) is an American folk/blues musician. She is the daughter of Sweet Honey in the Rock co-founder Bernice Johnson Reagon, with whom she has sometimes collaborated on musical projects and of Cordell Hull Reagon, a leader of the civil rights movement in Albany, member of the Student Nonviolent Coordinating Committee (SNCC), and co-founder of The Freedom Singers.

Reagon began performing when she dropped out of college; soon afterward, Lenny Kravitz invited her to open for him on his first world tour. She has since shared the stage with performers ranging from Ani Difranco to Elvis Costello.

Her band, BIGLovely, has been performing together since September 1996. The name allegedly comes from a love-letter she received from her girlfriend, which was addressed "To My BIGLovely." The band includes Judith Casselberry on acoustic guitar and vocals, Robert "Chicken" Burke on drums, Fred Cass, Jr. on bass, Adam Widoff on electric guitar, and Catherine Russell on mandolin and vocals. The line-up also includes Jen Leigh, Ann Klein, Debbie Robinson, Alison Miller, Kismet Lyles and Stephanie McKay as replacements.

Reagon lives in Brooklyn, New York with her partner and her daughter.